Welcome to the Foodborne Disease website. The sources of pathogens responsible for causing foodborne illnesses are pervasive. Food and its derivatives will invariably harbor a small concentration of pathogenic agents. When existing in minor proportions, these detrimental microorganisms do not give rise to any concerns. However, upon surpassing a particular threshold of contamination, they hold the capability to initiate sickness and potentially lead to fatal outcomes..

Wednesday, June 29, 2022

Shigella dysenteriae

Shigella bacteria cause an infection called shigellosis. Shigella cause an estimated 450,000 infections in the United States each year. Most people with Shigella infection have diarrhea (sometimes bloody), fever, and stomach cramps.

The four species of Shigella are:
*Shigella sonnei (the most common species in the United States)
*Shigella flexneri
*Shigella boydii
*Shigella dysenteriae

Shigella dysentery was the first associated enteric infection to be recognized. S. dysenteriae type 1 (not commonly present in the US, except in travelers returning from endemic areas) produces Shiga toxin, which causes marked watery diarrhea and sometimes hemolytic-uremic syndrome.

S. dysenteriae type 1 is the causative agent of the most severe form of bacillary dysentery, which occurs as epidemics in many developing countries. S. dysenteriae type 1 produces a potent cytotoxin (Shiga toxin) that causes local destruction of colonic epithelium, so disease due to this strain is more severe and prolonged than that produced by other species.

S. dysenteriae is a gram-negative bacterium that causes bacillary dysentery or shigellosis. S. dysenteriae spread by contaminated water and food, causes the most severe disease because of its potent exotoxin.

The disease can be divided into two phases.
*First phase: occurring in the first 1 to 2 days, consists of watery diarrhea and cramping; this phase is mediated by an enterotoxin. Process involves:
- Ingestion
- Noninvasive colonization and cell multiplication
- Production of the enterotoxin by the pathogenic bacteria in the small intestine

*Second phase: is caused by invasion of the organism into the large intestine and produces fever, cramps, bloody diarrhea, and tenesmus.
Shigella dysenteriae

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